Endocrine Abstracts

Objectives: The aim of this systematic review was assessment of clinical efficacy of pegvisomant (PEG) in the treatment of adult patients (age ≥18 years) with acromegaly.Methods: The review was conducted according to the Cochrane Collaboration guidelines and polish recommendations of The Agency for Health Technology Assessment and Tariff System. Since acromegaly is a rare disease, not only randomized clinical trials (RCTs), but also real world data...

Background: Syncope is a transient loss of consciousness resulting from cerebral hypoperfusion. Despite the extensive efforts by the scientific community over decades, the pathophysiology remains unclear. Although syncope itself is a reversible, short-lasting, benign condition, it negatively impacts quality of life. Vasovagal syncope (VVS) is a form of orthostatic intolerance (OI). Its clinical signs such as dizziness and hypotension may mimic symptoms of adrenal insufficiency...

Introduction: Adrenal scintigraphy using [131I]6ß-iodomethyl-19-norcholesterol has been available since 1975, primarily for the diagnosis of hyperaldosteronism helping to distinguish between unilateral adenoma and bilateral hyperplasia. First line treatment of ACTH-independent form of Cushing syndrome is surgery after localization of the cortisol-producing adrenal tumour.Case report: A 31-year-old woman has been referred to the endocrine ...

Surgery is the only effective therapy for insulinoma patients, therefore there is a necessity to develop diagnostic strategies in cases of unknown tumour location, possibly through the use of new biomarkers. 99mTc labelled glucagon-like peptide 1 analogue (99mTc-GLP1) scintigraphy has been developed in our centre as an imaging technique of insulinoma. Labelled GLP1 analogue might also be applied in diagnosis of various forms of nesidioblastosis allowing t...

Introduction: Combined pituitary hormone deficiency (CPHD) results in deficit of growth hormone and coexisting failure of synthesis or excretion at least another pituitary hormone. Transcription factors controlling expression of genes required for pituitary organogenesis are orchestrating entire development process and certain cell lineages differentiation, contributing therefore significantly to CPHD pathogenesis with childhood onset.Aims: The purpose o...

Introduction: The aim of this study was to assess the diagnostic efficiency of [Lys40(Ahx-HYNIC-99mTc/EDDA)NH2]-exendin-4 scintigraphy in the detection of hardly detectable or not diagnosed by other available method insulinomas.Materials and methods: 37 patients (24 women and 13 men, mean age 46.5±17.8 years, min. 16.0 years, max. 77.0 years) were enrolled in this study. There were 32 patients with clinical and bioch...

Objectives: Glucocorticoids (GCs) are the first line therapy in moderate to severe, active thyroid eye disease (TED). While their beneficial immunosuppressive effects are well known, direct connective tissue effects are less characterized. The accumulation of extracellular matrix component hyaluronan (HA) and increased proliferation rate of fibroblasts are hallmarks connective tissue changes in TED. We examined the effect of methylprednisolone (MP), prednisolone (P), hydrocort...

Introduction: Due to the frequent occurrence of adrenal incidentalomas, diagnosis of their hormonal activity is a significant clinical concern. Approximately 7-10% of adrenal tumors are pheochromocytomas, which even in silent form can lead to hemodynamic instability during surgery. According to the ESE and ENSAT guidelines in any case of adrenal tumors greater than 1 cm pheochromocytoma should be excluded based on plasma metanephrines level and urinary metanephrines excretion....

Von Hippel-Lindau (VHL) disease is an inherited tumour syndrome, caused by a mutation in the VHL tumour suppressor gene encoding the VHL protein. Patients are prone to cysts and neuroendocrine tumours in the pancreas and other benign and malignant neoplasms. Pancreatic cysts occur in approximately 70% of VHL patients. We describe two cases of VHL disease with extensive multi-cystic changes affecting the whole pancreas, both patients had deletions of exon 2–3 of the VHL ge...

Objective: Withdrawal of the medications prior to screening for primary aldosteronism is problematic, sometimes impossible and probably not necessary as the routine practice. The aim of this study was to evaluate diagnostic accuracy of aldosterone-to-renin ratio in hypertensive patients undergoing laboratory screening for primary aldosteronism without obligatory drug modifications.Methods: Plasma aldosterone and direct renin concentrations from 20 patien...